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Guo JQ, Lin H, Kantarjian H, Talpaz M, Champlin R, Andreeff M , Glassman A, Arlinghaus RB

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GLP-2R signaling is indispensable for jejunal villi length expansion in response to the increased food intake that accompanies chronic cold temperature housing The requirement of GLP-2R signaling to expand jejunal villi length and circumference in response to increased food intake with chronic cold stress was observed when comparing morphological results in DIRKO and GLPDRKO mice compared to WT controls

Due to its CNS action, the dual GLP- 1/GIP dual agonist exhibits these superior benefits [23]

demonstrates that GHK-Cu promotes ECM component synthesis while simultaneously modulating matrix metalloproteinase (MMP) activity (Pickart & Margolina, Biomedicines, 2018)