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However, science is particularly interested in it because of its many physiological, endocrine and modulatory effects, such as its ability to alter corticotropin levels, inhibit somatostatin secretion, normalize blood pressure, reduce stress, influence sleep rhythms, or chronic pain perception

An independent assessment committee evaluated the endpoints and determined threshold criteria for clinically meaningful responses before the trials unblinding

Precision was calculated as the relative standard deviation, whereas accuracy was considered as the percentage of analyte recovery using the following formula: accuracy (%) = 100% x (measured amount - endogenous content)/added amount

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Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57.5 (2008): 712-717