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All patients were 45 years or older, with an initial BMI of 27 kg/m2 or greater and established CV disease (prior myocardial infarction, prior stroke, or peripheral arterial disease)

This modest early drop is completely normal

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It gained considerable attention when the FDA approved its use to help obese and overweight patients reduce their risk of major adverse cardiovascular events, and Medicare even announced it would start covering semaglutide, a step previously unseen when it came to obesity medications