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Effects of oral ondansetron on pharmacokinetics of oral midazolam: the role of cytochrome P450 3A4

The analytical data obtained were found to be consistent with the previous literature 47

Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)