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TMAO is associated with pyroptosis of tumor cells via PERK-dependent ER stress, improving antitumor immune response via CD8 + T cells
However, their signaling diverges at later stages: in the tongue, activation of these receptors produces neurotransmission and conscious taste perception, whereas in the intestine, the same receptor types modulate hormone secretion (such as GLP-1 and GIP) through endocrine signaling pathways (48, 49)
Nutr Cancer 1994
Because human data are limited, any influence on malignancy-related processes remains an area requiring significant further research one reason the compound is restricted to experimental settings
Carnitinemetabolism and functions
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