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Additionally, therapeutic interventions that target MAPK signaling, such as the use of sakuranetin, have demonstrated efficacy in reducing eosinophilic lung inflammation and Th2/Th17 cytokine production by inhibiting the activation of ERK1/2, JNK, and p38 MAPKs [165]

This suggests that both the progression of MAFLD and the treatment with metformin significantly impact the local metabolic patterns in the rat liver

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