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Its primary effect is increased melanin production, which can lead to darker skin pigmentation with less sun exposure

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At 24 weeks, the mean relative change from baseline in liver fat was a 42.9% reduction in the 1 mg group, a 57.0% reduction at 4 mg, an 81.4% reduction at 8 mg, and an 82.4% reduction at the 12 mg dose

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We designed the study within the ECOG-ACRIN TMIST population, which includes more than 108,000 women worldwide who have been recruited, characterized for breast cancer risk, and undergoing regular screening for breast cancer, she said