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Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure
(PubMed) McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM
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Maintenance Dose A lower medication dose sufficient to maintain weight loss after its been achieved, typically 40-60% of the dose needed for active weight loss
Yes, in some cases a combination plan can make sense
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