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Several studies have reported that supplementing rats with both L-carnitine and alpha-lipoic acid halts age-related increases in reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, and DNA strand breaks in heart, skeletal muscle and brain, concomitant with improvement in mitochondrial enzyme and respiratory chain activities [146149]

Berberine Berberine is a natural compound found in several plants, including goldenseal and barberry

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GLP-1R agonists: recent advances, current gaps, and future challenges