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With the development of ADC approach, PBD has been used as a payload associated with specific antibodies in the treatment of different diseases, limiting the high toxicity associated with this molecule

coli ) as a model system amenable to our integrative approach including growth-complementation studies, biochemical activity assays, systematic single-particle cryogenic-electron microscopy (cryo-EM) and atomistic molecular dynamics (MD) simulations to characterize the structure and function of CydDC down to the molecular level

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Nrf2 has a dark side in that cancer cells can use a mutated form of this pathway to protect themselves against the bodys immune system and chemotherapeutic agents