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A stop-gain variant (p.Arg138*) in the Greenlandic population was associated with markedly reduced type 2 diabetes risk, a finding replicated in the UK Biobank, in which carriers of protein-truncating variants exhibited up to a 65% lower risk of developing diabetes

GLP-1 receptor agonists work by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through action on brain appetite centres

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The combination could produce additive or even synergistic improvements in these markers, which translates directly to reduced cardiovascular risk