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However, liver mitochondria from mice lacking ANT1 and ANT2 can still undergo Ca 2 + -induced swelling and MPT, although at a higher threshold, which has been interpreted as evidence against a role for ANT in MPT (Kokoszka et al., 2004)
Are we even measuring anything
These two events are mechanistically separable: extracellular domain binding affinity does not predict transmembrane domain activation efficiency, and mutations in the extracellular domain can selectively abolish -arrestin recruitment while preserving cAMP production
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