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We also speculate that the GDH pathway may also control the fate of the last reaction of the GABA shunt, which involves the degradation of GABA to -aminobutaric acid, instead of succinate, as previously described in S
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357,358 Thus, combinatorial strategies that block downstream pro-metastatic cytokines (e.g., IL-6 or CXCL8) or macrophage reprogramming may uncouple necroptosis from its deleterious consequences
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