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We found here that agonist trafficking properties, as well as insulin secretion, mirrored -arrestin recruitment propensity, contrasting with some 14,33 (but not all 34 ) previous work suggesting that -arrestins do not impact GLP-1R trafficking 14,34,35 , as well as reports of coupling of GLP-1R to insulin secretion via -arrestin-1 14 (although not -arrestin-2 60 )
Notably, metformin itself can impair B12 absorption, which makes the B12 in compounded semaglutide even more valuable for patients on both medications
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Researchers frequently compare semaglutide or tirzepatide and, like Ozempic-class compounds, it acts on incretin signalling rather than a single receptor
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