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BAC = (1.8 x 5.14) / (180 x 0.73) - (0.015 x 2) = 9.252 / 131.4 - 0.03 = 0.0704 - 0.03 = 0.040%

doi.org/10.1056/NEJMoa2206038 9Wilding J.P.H

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That distinguishes it from Long R3 IGF-1, whose N-terminal extension has no counterpart in human physiology

On the basis of learnings from that trial, the oral semaglutide dose in the subsequent food-effect trial was gradually increased from 5 mg during the first 5 days to 10 mg during the last 5 days to mitigate the risk of gastrointestinal AEs