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[44] Brass EP.Ann N Y Acad Sci
Our sensitivity analysis with exenatide suggests that NAION may be unique to semaglutide, indicating a mechanism beyond transient glucose reductions associated with GLP-1 RAs. The growing compendium of research exposing the ocular risks associated with GLP-1 RAs is concerning as the popularity of these drugs continues to rise, though more prospective studies are still needed to clarify the mechanisms behind these associations
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Clinicians must visually inspect the oral cavity, obtain good clinical histories, and be willing to perform a biopsy in any condition that is not readily diagnosed
Alternative causes include anxiety, thyroid dysfunction, anaemia, caffeine intake, and pre-existing cardiac conditions
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