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Persistently elevated IGF-1 has been associated with increased risk of certain cancers in epidemiological studies (Renehan et al., Lancet 2004)
This review aims to summarize the role of the oxidative stress in the pathogenesis of AD, focusing in the main oxidative products (DNA, protein, and lipid oxidation products), as well as antioxidant therapeutic approaches involving natural products, nanomaterials, hydrogels, and microneedles
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