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18 TGF- functions through its interaction with TGF- receptors, which phosphorylate SMAD2/3, allowing these proteins to form complexes with SMAD4 that translocate to the nucleus and regulate gene expression

GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

(2006) Prolonged Stimulation of GH and IGF-1 Secretion by CJC-1295, a Long-Acting Analogue of GHRH, in Healthy Adults J Clin Endocrinol Metab 91(3):799805

Este mecanismo es farmacolgicamente plausible y tiene respaldo en varios ensayos del mismo grupo de investigacin

This has been linked particularly with the ability of ATB 0,+ to mediate high capacity transport of amino acids (Gupta et al., 2006