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That means semaglutide mimics the action of a hormone called glucagon-like peptide-1. That hormone, GLP-1, is very important for blood sugar management
1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG
doi: 10.1016/B978-0-12-816402-0.00004-5 69 TehSSNivenBEBekhitAEDACarneABirchEJ
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