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(2014b)

Gout especially favors the bunion joint, known as the first metatarsophalangeal joint (at the base of the big toe), but the ankle, midfoot and knee are also common locations, as is the bursa that overlies the elbow

Major trials include REDEFINE 1 (adults with obesity, published in NEJM) and the REIMAGINE trials (adults with type 2 diabetes), both evaluating CagriSema against semaglutide alone or placebo.

The gradual reduction allows assessment of the minimum effective dose for each individual

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