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Nutrients 2018, 10, 349

Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]

[5] Patients prescribed GLP-1 agonists often have type 2 diabetes or obesity, conditions independently associated with increased rates of osteoarthritis and other musculoskeletal disorders

& Bartley, J

If semaglutide isn't producing the desired effect after 8-12 weeks, your PlexusDx clinician can transition you to tirzepatide (which targets an additional metabolic pathway) or GLP-Squared (combining both compounds)