tirzepatide discontinuation GLP-1RA and tirzepatide: undermines cardiometabolic gains and may amplify long-term CV risk Stopping Tirzepatide: Weight Rebound &

Abbreviations TT: Testicular torsion I/R: Ischemiareperfusion IR-I: Ischemiareperfusion injury PRP: Platelet-rich plasma PC: Post-conditioning LT: Left testis i.t: Intratesticular i.p: Intraperitoneally MDA: Malondialdehyde CAT: Catalase GSH: Reduced glutathione eNOS: Endothelial nitric oxide synthase HSP70: Heat shock protein 70 VEGF: Vascular endothelial growth factor TNF-: Tumor necrosis factor alpha IL-6: Interleukin-6 NF-B: Nuclear factor kappa B Bax: Bcl-2-associated X protein ROS: Reactive oxygen species PAS: Periodic acidSchiff H&E: Hematoxylin and eosin Hb: Hemoglobin RBCs: Red blood cells HCT (PCV): Hematocrit (packed cell volume) MCV: Mean corpuscular volume MCH: Mean corpuscular hemoglobin MCHC: Mean corpuscular hemoglobin concentration References Akhigbe, R

It helps neutralize free radicals, supports liver detoxification, boosts immunity, and promotes cellular repair

Del Prete A, Iadevaia M, Loguercio C (2012) The role of gut hormones in controlling the food intake

Promise treating addiction This communication spans specialties beyond what one might expect for GLP-1 drugs

"GLP-1 and muscle loss" is one of the most searched concerns among patients considering GLP-1 therapy, and the clinical evidence supports the concern