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For the earlier window mild cognitive impairment (MCI) and brain aging where synaptic loss is the dominant driver of symptoms and where the 2026 NICE rejection of lecanemab and donanemab has left a substantial UK treatment gap, the synaptic-rationale conversation continues even after the fosgonimeton failure
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DOI:10.17245/jdapm.2022.22.2.97
miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines
Tissue type considerations further support synergistic combinations
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