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The efficacy of setmelanotide may not be sufficient for POMC-MC4R deficient patients because body weight reduction ratio of semaglutide and tirzepatide were 12.4 and 17.8%, respectively in clinical study as compared with that of setmelanotide, 5.2% [[18, 19, 23]]
Monteleone G, Neurath MF, Ardizzone S, Di Sabatino A, Fantini MC, Castiglione F,
There is limited data suggesting that L-carnitine may aid in muscle recovery, but more data is needed to prove benefit
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