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Clark J, Martin E, Bulka CM, Smeester L, Santos HP, OShea TM et al
The study, which ended prematurely due to a higher mortality rate in the intensive treatment group, failed to report significant reduction in major cardiovascular events, giving a notion that intensive therapy was associated with significant harm in high risk patients [6]
A number of clinical observations suggest that Down patients may have a functional folate deficiency despite having normal plasma levels of folate and vitamin B 12 [13]
Weight loss continues progressively for 12 to 18 months before plateauing, with maximal effects requiring sustained treatment at maintenance doses
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