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This oxidation of proteins may create reactive and toxic oxygen species, such as hydrogen peroxide, leading to direct cell toxicity and apoptosis,

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Os desfechos coprimrios avaliados foram: Reduo percentual do peso corporal Reduo da dor no joelho (escala WOMAC) Principais resultados do TRIUMPH-4 Perda de peso clinicamente relevante Reduo mdia de at 28,7% do peso corporal ( 32,3 kg ) com a dose de 12 mg Cerca de 40% dos pacientes alcanaram 30% de perda ponderal , um resultado raro em terapias farmacolgicas Para o farmacutico, esses dados reforam o potencial impacto futuro no manejo da obesidade grave e de suas complicaes