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279,280 PU-H71 suppresses cell survival and promotes DNA damage accumulation by inhibiting RAD51 and Ku70 expression and is currently under clinical evaluation, including in combination with carbon-ion radiotherapy
Hendrix MLE, Palm KCM, Van Kuijk SMJ, Bekers O, Spaanderman MEA, Bons JAP, et al
There are dozens of different reasons that your intestinal barrier could be weakened
Keep in mind, though this is all animal data
It has been reported that treatment with UK-5099, an inhibitor of mitochondrial pyruvate carrier (MPC), reduces the cellular GSH level by diverting glutamine metabolism from GSH synthesis in tumor cells 37
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