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Bhles H, Evangeliov A, Bervoets K, Eckert I, Sewell AC (1994)
By virtue of their peptide character, the peptidomimetic inhibitors have poor pharmacokinetics due to susceptibility to metabolic cleavage by peptidases
Think of it as a next-generation version of drugs like Ozempic (which hits one receptor) and Zepbound (which hits two)
This applies to patients who fail to achieve individualised glycemic targets despite receiving metformin and an SGLT2 inhibitor (SGLT2i) or who have a contraindication to these medications [16]
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