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To ensure that the glutathione stays intact and reaches the cells where it is needed, it must be protected during its journey through the digestive tract

However, during an initial loading phase, a more frequent schedule may be necessary

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Differential induction of glutathione S-transferase in rat aorta versus liver [PMID: 8204108] Laboratory literature summary: Differential induction of glutathione S-transferase in rat aorta versus liver

Glutathione levels change over the course of a lifetime and in response to a range of factors