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MOTS-C with repair peptides like BPC-157 or TB-500 makes sense if you're dealing with both metabolic goals and a tissue or gut issue
Cost is a significant consideration for many patients, and neither medication is cheap
Ozempic brought in $20.1 billion, and Wegovy added $12.5 billion
Native GLP-1 and GIP have limited pharmacologic value because of their short plasma half-life (17 min) (19)
Post-marketing surveillance through the FDA Adverse Event Reporting System (FAERS) and clinical experience suggest that some patients do report sleep changes after starting tirzepatide
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