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Although the SUSTAIN-6 trial illustrates that diabetic patients taking subcutaneous semaglutide are not at increased risk of developing acute pancreatitis, clinicians may need to consider discontinuation of this GLP-1 receptor agonist in patients who present with Acute Pancreatitis while taking this class of medication, particularly if they have other risk factors for acute pancreatitis
Thigh injections may produce a slightly lower and later peak compared to abdominal injections
1997 May;144(1):62-9
Those who started at 4mg saw faster initial appetite effects but also experienced higher rates of nausea and other gastrointestinal side effects
Severe, worsening, or functionally impairing fatigue warrants prompt clinical review
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