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The sensitivity and subgroup analyses were performed on matched groups unless stated otherwise

As of early 2026, multiple Phase 3 trials have reported positive topline results, regulatory submissions have been filed, and the FDA is reviewing orforglipron for an obesity indication with a target action date of April 10, 2026

Today, 12% of U.S

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185: 2935 Minkler PE, Hoppel CL