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The regulator is set to announce its decision by Dec

Although the etiology of depression has not been fully elucidated, current scientific data emphasize the role of neurotrophic factors deficiencies, disturbed homeostasis between the nervous system and the immune and endocrine systems, as well as disturbances in brain energy metabolism and dysfunctions in the gut-brain axis as important factors in the pathogenesis of this neuropsychiatric disorder

Clinical trials demonstrate that weekly semaglutide injections produce sustainable weight loss with effects visible within 4 to 6 weeks of treatment initiation

Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)

In this way, we only included new SGLT-2i or GLP-1RA users with obesity when initiating therapy, in order to produce groups as similar as possible at baseline