ozempic semaglutide or tirzepatide Why You Might Tolerate One Weight Loss Drug Better Than Another Ozempic, other GLP-1 weight loss

GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

Microdosing tirzepatide is more complex than semaglutide because of the dual receptor engagement, but both GLP-1 and GIP respond well to sustained lower levels

Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]

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This metabolic adaptation is one reason why weight maintenance is often harder than initial weight loss