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Some appear to influence the brain circuits involved in stress and mood
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Other research, including a 2025 study published in Nature Medicine , has explored potential links between GLP-1 use and lower risks of conditions such as substance use disorders and dementia
Still outstanding: TRIUMPH-5 (head-to-head vs tirzepatide) TRIUMPH-6 (weight maintenance) and the MASH / MASLD readouts TRIUMPH-Outcomes (cardiovascular and kidney outcomes) -- a multi-year, event-driven trial Lilly said it plans to submit a Biologics License Application (BLA) for retatrutide to the FDA in the first quarter of 2027 , based on the core TRIUMPH results and supporting filings for obesity, obstructive sleep apnea, and knee osteoarthritis
They may refer you to an allergist for further testing
