GLP-1 levels spike right after surgery, hit their peak in the first year or two, and then slowly start to fade
It spills over to MC3R and MC4R, triggering off-target effects
Differential Regulation of Carnitine Palmitoyltransferase-I Gene Isoforms (CPT-I Alpha and CPT-I Beta) in the Rat Heart
For context on how these results compare with single-agonist options, semaglutide (Wegovy) achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial, and retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24.2% weight loss in Phase 2
And again, where I'm going with this and I feel like I don't feel like I'm running out of questions, but I'm trying to really bring home the point of it's so easy to gain weight, and it's so easy to blow it off until you at a point where all these things, like you said, are now in play