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The types of adverse events seen were generally consistent with trials of other incretin-based therapies
FDA scientists, who were largely ignored at last weeks meeting, argue that even if peptides are made by US pharmacies, these products are still untested, unproven, and we dont know if theyre safe
Current evidence generally presents two concurrent perspectives: Absence of distinct teratogenic signals: aggregated data from registries, cohorts, and systematic reviews indicate that brief exposure to GLP-1RAs in early pregnancy has not been associated with a stable increase in the risk of major structural malformations or miscarriage (44, 165, 166)
Dosage and titration vary based on provider discretion
Semaglutide targets the GLP-1 receptor alone, whereas Tirzepatide acts as a dual GLP-1/GIP agonist, often providing superior appetite suppression and metabolic control
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