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Many individuals begin to experience early improvements, such as reduced cravings and better control over eating habits, within the first few weeks
Vomiting, diarrhea, and constipation occur in 20 to 30% of active-drug participants
Wei et al
However, berberine increased the live birth rate more than metformin and did so with fewer side effects than metformin
These symptoms peak in the first 48 weeks at each new dose level because GLP-1 receptor density in the gut exceeds that in the hypothalamus
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