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These shifts may come and go at first, especially while doses are still low, but often become more consistent as treatment continues and doses go up
However, over-exercising can backfire by causing oxidative stress
Two complementary routes merit evaluationbehavioral prehabilitation (exercise) to enrich high-formate microbial output, and timed 1 C-donor regimens (formate salts or methanol pro-drugs) co-administered with ICIwhile prioritizing dose/schedule optimization, T-cell-directed delivery, and biomarker-guided selection (plasma/fecal formate
Nat Immunol 22:7
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