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Possible minor side effects include vein irritation or slight discomfort at the injection site
A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide
The cardio-protective effects outweigh the modest tachycardia in most patients with CV disease
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Is 12 mg always better than 8 mg
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