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Gene-gene interactions Table 1 clearly shows that many authors reported an increased maternal risk of birth of a child with DS for carriers of combined genotypes given by the presence of two simultaneous risk alleles, mainly combinations of MTHFR 677T and 1298C alleles, or combinations of MTHFR 677T and MTRR 66G ones (Table 1)
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10.3390/nu5093481 76 Obermann-BorstS
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