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The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after initial weight loss regained significant weight (approximately 14% regain over 52 weeks following randomized withdrawal), while those continuing treatment maintained their weight loss, confirming ongoing medication efficacy

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miRNAs The expression of many miRNAs in pancreatic beta cells is altered in diabetic states, providing a potential (if still highly challenging) therapeutic approach [27]

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