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It has been shown that, following type IV pili-mediated contact, the pilE gene encoding the major pilin and the genes for capsule synthesis are downregulated, and this is thought to allow for more intimate adhesion through other outer membrane adhesins
However, new targets from detailed molecular mechanistic analyses and improved gene therapy delivery technologies, such as using non-viral, nanoparticle-based DNA delivery mentioned below, provide renewed optimism
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
10.1016/j.jphs.2019.05.005 39 CanizaresO.Uribe JaramilloF.Kerdel VegasF
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