As gastrointestinal cancer outcomes were secondary or exploratory endpoints in the majority of included trials, these analyses are inherently vulnerable to type I error, outcome misclassification, and inadequate statistical power
Patients should contact their GP or healthcare provider urgently if they experience: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Persistent vomiting or inability to keep fluids down (risk of dehydration) Difficulty swallowing or painful swallowing Unexplained weight loss Vomiting blood or passing black stools (seek immediate emergency care) Note that the 3 mg dose of Rybelsus is only for treatment initiation (30 days), and dose escalation to 7 mg (and later 14 mg if needed) can be delayed if gastrointestinal side effects persist
Sally Seymour, director of the Division of Pulmonology, Allergy, and Critical Care in the FDAs Center for Drug Evaluation and Research, said in a news release
Visual changes become dramatic
Fadilah NIM, Nizam NAAK, Fauzi MB