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Additional research indicated that the proper function of STAT3 is critical for maintaining intestinal homeostasis, and constitutive activation of the STAT3 signaling pathway in epithelial cells reduces tight junction protein expression within endothelial cells, consequently enhancing vascular permeability and contributing to tissue damage and disease progression (Spalinger et al., 2021)

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10.1016/j.pmpp.2015.09.001 71 HoG

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This increased oxygen consumption leads to the production of more free radicals and oxidative stress, which causes damage to cells and tissues