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Individuals with diabetes characterized by HbA1c 6.5%, or a history of surgical or device-based obesity treatment, were excluded

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(2025) Although there is extensive evidence that mechanisms of APAP hepatotoxicity translate to human overdose patients, the vast majority of experiments are performed in young and healthy male mice, which does not reflect the entire spectrum of patients in terms of age, sex, pre-existing conditions, consumption of multiple drugs, etc

Markesbery WR

In the STAIR XI meeting this point was made more explicit and recommended to be taken into account in the design of preclinical studies [25, 26]