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They promote energy production and fat metabolism

The muscle-sparing effect represents a significant advantage for body recomposition goals

Key considerations if a patient discloses combined use include: Gastrointestinal effects : Both agents may independently cause nausea, vomiting, or appetite suppression

while the acute repletion might be IV/IM for a period, they may transition to high-dose oral vitamins thereafter

Metabolic approaches: GLP-1 Incretins (semaglutide): appetite suppression | GLP-1/GIP incretins (tirzepatide): dual hormonal agonism | 5-Amino-1MQ: NNMT enzyme inhibition a non-hormonal mechanism, directly targeting lipid and NAD+ metabolism