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Semaglutide has been shown to cause dose-dependent and treatment duration-dependent malignant thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice
A diagnostic trial utilizing physiologic doses of vitamin B12 (1 mcg daily) and observing daily reticulocyte counts after establishing a baseline may also be performed
For severe deficiency, clinicians typically prescribe loading doses daily or every other day for one to two weeks followed by monthly maintenance injections
Both drugs spent 20222024 on the FDA drug shortage list
10 mg vial + 2.0 mL = 5 mg/mL
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