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PubMed Blondeau JM

32 Women over 35 years old in particular have a higher risk of infertility, lower chance of benefiting from treatment, and greater likelihood of poor pregnancy outcomes

In silico examination of CBS promoter by Jaspar software 38 predicted one putative antioxidant response element (ARE) ~ 5 kb upstream of the transcription start site, which is highly associated with H3K4Me1, H3K4Me2, H3K4Me3, and H3K9Ac histone marks (Supplementary Fig

Worthy of mention, a rise in the prevalence of subclinical autoimmune hypothyroidism and thyroid autoantibodies has been reported after iodine supplementation in iodine-deficient countries, likely in relation to enhanced immunogenicity of thyroglobulin [27]