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M1 macrophages stimulated with LPS exhibit biphasic and transient increases in NAD + levels associated with the release of TNF- (104)

In addition, they are associated with an increased heart rate, typically by 23 beats per minute [11], although the clinical relevance of such effects is uncertain [10]

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Following this initial patient characterization, mutations in the GATM gene and the SLC6A8 gene were found in patients exhibiting similar pathology to that seen with mutations in the GAMT gene

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